Effect of stanford pouch and ileal conduit urinary diversions on bone mineral density and metabolism


Incel N., Incel N. A. , Uygur M. C. , Tan O., Erol D.

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.38, pp.447-451, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38
  • Publication Date: 2006
  • Doi Number: 10.1007/s11255-005-8435-0
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.447-451
  • Keywords: bone mineral density, ileal conduit, Stanford pouch, urinary diversion, INTESTINAL DIVERSION, BLADDER SUBSTITUTION, CONSEQUENCES, SEGMENTS, COMPLICATIONS, RESERVOIR

Abstract

After urinary-intestinal diversions metabolic complications may occur in long term follow up. We aimed to evaluate bone metabolism changes in urinary diverted patients. Nineteen patients with urinary diversions (11 Stanford pouch and 8 ileal conduit) performed with diagnosis of locally invasive bladder cancer and 19 age-sex matched healthy subjects were enrolled in the study. Bone mineral density (BMD), arterial blood pH, bicarbonate and base excess as well as bone mineralisation parameters at urine and serum were evaluated for all groups. For statistical evaluation, nonparametric comparisons between groups were used. Comparison of ileal conduit and control groups displayed higher alkaline phosphatase and parathormone levels in the patient group though the difference was not significant. The mean BMD values of ileal conduit group were osteopenic, revealing a significant difference with the control group. Statistically significant differences between alkaline phosphatase, parathormone levels of Stanford pouch and control groups were apparent whereas BMD values were not significantly different. When the two patient groups were compared with each other, no difference in BMD or bone metabolism parameter values could be observed. Patients with urinary diversions are under risk of bone demineralisation and must be followed by BMDs, arterial blood analysis and bone mineral metabolism parameters.