Role of food-drug interactions in neurological and psychological diseases


Creative Commons License

GEZMEN KARADAĞ M., ÇELİK E., Kadayifci F. Z. , Yesildemir Ö., ÖZTÜRK Y., AĞAGÜNDÜZ D.

ACTA NEUROBIOLOGIAE EXPERIMENTALIS, vol.78, no.3, pp.187-197, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 78 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.21307/ane-2018-017
  • Journal Name: ACTA NEUROBIOLOGIAE EXPERIMENTALIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.187-197
  • Keywords: neurological diseases, psychological diseases, food-drug interaction, SEROTONIN REUPTAKE INHIBITORS, VALPROIC ACID, PARKINSONS-DISEASE, SERUM-LEVELS, ANTIEPILEPTIC DRUGS, YOUNG-ADULTS, WEIGHT-GAIN, L-DOPA, HOMOCYSTEINE METABOLISM, BIOTIN SUPPLEMENTATION
  • Gazi University Affiliated: Yes

Abstract

Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food-drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food-drug interaction in the treatment of neurological and psychological diseases. A literature search was carried out by collecting data from different reviews, reports, and original articles on general or specific drug interactions with food, in patients with a variety of neurological and psychological diseases. Based on our review, we found that food-drug interactions may alter the expected impact of drug, or cause the development of a drug toxicity. Nutritional status of the patients may also be affected, particularly a change in body weight caused by a change appetite. Metabolism, absorption, and excretion of foods may also be altered, and nutritional insufficiencies may occur. Recent studies show that diet can have a strong influence on gut microbiota and thus, alter drug pharmacokinetics. Therefore, microbiota alterations should also be considered while assessing food-drug interactions. Knowledge of food-drug interactions is critical for improving health of patients with neurological and psychological diseases, and also for improving effectiveness of treatments.