Allostatic load in patients with type ii diabetes


Macit S., Acar Tek N.

22nd European Congress on Obesity (ECO2015), Praha, Çek Cumhuriyeti, 6 - 09 Mayıs 2015, cilt.8, ss.216

  • Cilt numarası: 8
  • Basıldığı Şehir: Praha
  • Basıldığı Ülke: Çek Cumhuriyeti
  • Sayfa Sayıları: ss.216

Özet

Objective: Optimal glycemic control is necessary to prevent and extend the complications of diabetes. If the regulation couldn’t be maintained, homeostasis is interrupted in consequence of altered metabolic processes. Chronic dysregulation of physiological systems may lead allostatic load (AL). The aim of the present study was to investigate the association of AL biomarkers in patients with diabetes that who gained control with blood glucose regulation or not. Methods: Total 103 patients with diabetes enrolled from the outpatient clinic of Endocrinology and Metabolism of Ondokuz Mayıs University. Patients divided into two groups which are unregulated and regulated diabetes, according to HbA1c levels higher and lower than 6.5%. Twelve biomarkers were used; fasting blood glucose, blood pressure, body mass index (BMI), waist/hip circumference, total cholesterol, HDL cholesterol, HbA1c (%), body fat percentage, serum C-reactive protein (CRP), albumin, cortisol , DHEA-S levels to asses AL. Values within higher than the referances were scored as 1 while those falling below the referances scored as 0. AL indices ranged from 0 to 12. Results: The study was carried out on 30 male (29.1%) and 73 female (70.9). The mean ages of the patients were found 46.46 ± 5.973 years. Mean AL score among the sample having unregulated and regulated blood glucose was 5.1 ± 1.18 and 4.32 ± 1.64, respectively. The difference between groups was statistically significant (p < 0.05). Biomarkers that contribute to allostatic load score were evaluated, mean CRP levels were 4.6 ± 2.06 mg/dL, fasting blood glucose were 113.5 ± 23.45 mg/dL in the sample that having regulated blood glucose and mean CRP levels were 7.39 ± 8.71 mg/dL, fasting blood glucose were 165.04 ± 52.99 mg/dL in the sample that having unregulated blood glucose. Dietary carbohydrate percentage of energy was higher (42.1 ± 6.48%) in the unregulated group than the regulated group (42.1 ± 6.48%) but not statistically significant. The difference between total energy, fat and sodium amount of dietary intakes were different between groups (p < 0.05). Diabetes duration represents statistically significant correlation with AL (r: 0.201) and HbA1c (r: 0.489). Conclusion: Poor glycemic control have negative effects on AL biomarkers and allostatic adaptation is impaired in uncontrolled diabetes