22nd European Congress on Obesity (ECO2015), Praha, Çek Cumhuriyeti, 6 - 09 Mayıs 2015, cilt.8, ss.216
Objective: Optimal glycemic control is necessary to prevent and extend
the complications of diabetes. If the regulation couldn’t be maintained,
homeostasis is interrupted in consequence of altered metabolic processes.
Chronic dysregulation of physiological systems may lead allostatic load
(AL). The aim of the present study was to investigate the association of AL
biomarkers in patients with diabetes that who gained control with blood
glucose regulation or not.
Methods: Total 103 patients with diabetes enrolled from the outpatient
clinic of Endocrinology and Metabolism of Ondokuz Mayıs University.
Patients divided into two groups which are unregulated and regulated diabetes, according to HbA1c levels higher and lower than 6.5%. Twelve
biomarkers were used; fasting blood glucose, blood pressure, body mass
index (BMI), waist/hip circumference, total cholesterol, HDL cholesterol,
HbA1c (%), body fat percentage, serum C-reactive protein (CRP), albumin, cortisol , DHEA-S levels to asses AL. Values within higher than the
referances were scored as 1 while those falling below the referances scored
as 0. AL indices ranged from 0 to 12.
Results: The study was carried out on 30 male (29.1%) and 73 female
(70.9). The mean ages of the patients were found 46.46 ± 5.973 years.
Mean AL score among the sample having unregulated and regulated
blood glucose was 5.1 ± 1.18 and 4.32 ± 1.64, respectively. The difference
between groups was statistically significant (p < 0.05). Biomarkers that
contribute to allostatic load score were evaluated, mean CRP levels were
4.6 ± 2.06 mg/dL, fasting blood glucose were 113.5 ± 23.45 mg/dL in the
sample that having regulated blood glucose and mean CRP levels were
7.39 ± 8.71 mg/dL, fasting blood glucose were 165.04 ± 52.99 mg/dL in
the sample that having unregulated blood glucose. Dietary carbohydrate
percentage of energy was higher (42.1 ± 6.48%) in the unregulated group
than the regulated group (42.1 ± 6.48%) but not statistically significant.
The difference between total energy, fat and sodium amount of dietary
intakes were different between groups (p < 0.05). Diabetes duration represents statistically significant correlation with AL (r: 0.201) and HbA1c
Conclusion: Poor glycemic control have negative effects on AL biomarkers and allostatic adaptation is impaired in uncontrolled diabetes