Correlation between intrahepatic hepatitis B virus cccDNA levels and other activity markers in patients with HBeAg-negative chronic hepatitis B infection

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Guner R., Karahocagil M., Buyukberber M., Kandemir O., URAL O., USLUER G., ...More

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.23, no.12, pp.1185-1191, 2011 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 23 Issue: 12
• Publication Date: 2011
• Doi Number: 10.1097/meg.0b013e32834ba13a
• Journal Name: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1185-1191
• Keywords: hepatitis B core antigen, hepatitis B early antigen-negative chronic hepatitis, hepatitis B surface antigen, hepatitis B virus, hepatitis B virus covalently closed circular DNA, immunohistochemistry, quantitative hepatitis B surface antigen, HBV DNA LEVELS, CLOSED CIRCULAR DNA, SURFACE-ANTIGEN, NATURAL-HISTORY, LIVER HISTOLOGY, HBSAG LEVELS, CORE, THERAPY, DECLINE, REPLICATION
• Gazi University Affiliated: Yes

Abstract

Objective The aim of this study was to demonstrate the relation between intrahepatic (IH) hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) levels and the other HBV replicative intermediates and hepatocyte expression of HBV antigens.