Single agent gemcitabine in the second-line treatment of advanced non-small cell lung cancer after treatment with taxane plus platinum regimens


Coskun U., Kaya A. O. , Buyukberber S., Benekli M., ÜNER A. , Dikilitas M., ...Daha Fazla

MEDICAL ONCOLOGY, cilt.25, sa.2, ss.133-136, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Konu: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s12032-007-9005-3
  • Dergi Adı: MEDICAL ONCOLOGY
  • Sayfa Sayıları: ss.133-136

Özet

In this study, we investigated the activity of single agent gemcitabine in the second-line setting of non-small cell lung cancer (NSCLC). File records of 21 patients treated with single agent gemcitabine in advanced NSCLC who received one prior chemotherapy including a taxane and platinum combination were retrospectively evaluated. Treatment consisted of IV gemcitabine 1,250 mg/m(2) on days 1 and 8, followed by a 1-week rest repeated every 3 weeks. A partial response was achieved in four (19%) patients. The median response duration was 16 (range, 12-32) weeks. Six (29%) patients had a SD more than 3 months. The median time to progression was 16 (range, 8-32) weeks. No complete response was observed. Median overall survival was 36 weeks for second-line gemcitabine in all patients (95%: CI 5-13 months). Hematological toxicity (all grades) was reported by 9 (42.9%) patients. One (4.75%) patient experienced grade 3/4 neutropenia. Grade 3/4 nausea and vomiting and mucositis were reported in one (4.75%) patient. In conclusion, this study shows that single agent gemcitabine is active and well tolerated as a second-line therapy for advanced NSCLC.