Sirtuin 1 Levels in Recurrent Implantation Failure

Engin-Ustun Y., Ozgu-Erdinc A. S., Caglayan E. K., Gulerman C., SARIKAYA E., Aktulay A., ...More

REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA, vol.39, no.10, pp.541-544, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 10
  • Publication Date: 2017
  • Doi Number: 10.1055/s-0037-1606349
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.541-544
  • Keywords: recurrent implantation failure, sirtuin, pregnancy, in vitro fertilization, WOMEN, METABOLISM, EXPRESSION, PREGNANCY, UTERINE, ROLES
  • Gazi University Affiliated: Yes


Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). In this cross-sectional study, we included 28 women with RIF, 29 healthy women who had conceived by in vitro fertilization (IVF), and 30 women with a 1-cycle failure of IVF as controls. Human serum nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1/SIRT2L1) levels were detected using a commercial colorimetric kit. Recurrent implantation failure patients have higher sirtuin 1 levels than non-pregnant women and healthy pregnant women, but this difference did not reach statistical significance due to the low number of patients in our study. These higher sirtuin 1 levels may result from the inflammation imbalance of RIF patients. The only statistically significant correlation found was between age and sirtuin (r = 0.277, p = 0.009).