Akademik Veri Yönetim Sistemi
Journal of Photochemistry and Photobiology, cilt.8, 2021 (Scopus)
Light-emitting diode (LED) irradiation has been used as a therapeutic technique for several diseases. It is known that energy levels of light change according to different surfaces, colors and geometric shapes. However, more information is needed regarding the effect of this change on the human body. This study was aimed to investigate the effect of blue LED light applied through an optical path with special geometry on the human dermal fibroblast (HDF) and cancer cell proliferation, apoptosis, migration, and cell cycle. The number of cancerous cells was found to be lower and the rate of necrosis was determined to be significantly higher in the geometrical light-treated group than in the direct light and non-light groups. The migration of HDF cells in blue LED light in the geometrical tool group increased more than the other groups after 72 h of light irradiation. In cancer cells, the wound closure rate of the non-light group was higher than light-exposed groups after 72 h. Blue LED light induces a G1 phase peak followed by apoptosis in cancer cells 24 h after light irradiation, especially in the geometrical tool group. These results indicate that blue LED irradiation applied through an optical path with a special geometrical tool inhibits cancer cell proliferation, migration, and induces cell necrosis.