Purpose: This study was planned to investigate depression, anxiety and quality of life (QoL) and psychosocial support needs of mothers have a child with disabilities.Methods: Forty mothers who have a child with 10 amputees, 10 cerebral palsy (CP), 10 mental retardation (MR), and 10 healthy children between 4-9 years of age participated in the study. Demographic information of children and mothers, time spend for caring and income level were determined. Nottingham Health Profile (NHP), Child Health Questionnaire Parent Form (CHQ-PF50), State-Trate Anxiety inventory (STAi-i, STAi-ii), and Hospital Anxiety and Depression Scale were used to determine QoL and psychological status of mothers.Results: No differences were determined between the groups in terms of mothers and children age (p>0.05). When the groups were compared, differences in terms of STAi-i were found between amputee/CP and healthy groups (p<0.05). The differences in STAi-ii were shown between amputee and the other groups against of amputee group (p<0.05). There was no difference in terms of anxiety between the groups (p>0.05), but depression scores were found different between amputee and healthy groups (p<0.05). Energy level and social isolation of NHP were found different against of amputees (p<0.05). Significant differences were found between all disability groups and healthy group in terms of physical functioning, general health perception and restrictions in role performance and social participation due to emotional status of the CHQ-PF50 (p<0.05).Discussion: it was determined that QoL, anxiety, depression levels, and psychologies of the mothers who have disabled children were affected negatively. Therefore, to cope with these situations, they should be referred psychosocial support programs.