Opioid Administration for Mucositis-related-Pain Using Patient Controlled Analgesia (PCA) Method is Associated with the Development of Early Posttransplant Complications

gürün, kübra; YEGİN, ZEYNEP; Akçalı, DİDEM; ÖZKURT, ZÜBEYDE; tertemiz, oktay; CAN, FERDA; DİKYAR, ASENA; berkiten, suzan

doi:10.5505/aot.2023.87360

Opioid Administration for Mucositis-related-Pain Using Patient Controlled Analgesia (PCA) Method is Associated with the Development of Early Posttransplant Complications

Atıf İçin Kopyala

gürün k., YEGİN Z. A., Akçalı D., ÖZKURT Z. N., tertemiz o., CAN F., ...Daha Fazla

ACTA ONCOLOGICA TURCICA, cilt.56, sa.2, ss.125-135, 2023 (Hakemli Dergi)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 56 Sayı: 2
Basım Tarihi: 2023
Doi Numarası: 10.5505/aot.2023.87360
Dergi Adı: ACTA ONCOLOGICA TURCICA
Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.125-135
Gazi Üniversitesi Adresli: Evet

Özet

Introduction: Mucositis is one of the major complications of allogeneic hematopoietic stem cell transplantation with myeloablative conditioning. Several measures have been developed to improve pain palliation and quality of life in transplant recipients. This study was performed to evaluate the association of opioid administration using patient controlled analgesia (PCA) method with early posttranplant complications. Materials and Methods: Medical records of 452 patients [median age: 35(15-67) years, male/female: 285/167] were retrospectively reviewed. Results: PCA was used in 157 patients (34.7%) for median 9(1-24) days. The proportion of patients who received myeloablative conditioning regimen was significantly higher in PCA+ group (p<0.001). Severe mucositis was more common in patients who required PCA administration (p<0.001). Total body irradiation (p<0.001) and methotreaxate prophylaxis (p<0.001) were more frequently used in PCA+ patients. Hypoxia, bleeding, sinusoidal obstruction syndrome, invasive fungal infections, neurotoxicity, hepatotoxicity and nephrotoxicity were significantly more common in PCA+ patients. Duration of hospitalization was significantly longer in PCA+ group (p<0.001). Discussion: Opioid administration with PCA, which was more frequently used in patients who had myeloablative conditioning and mucositis, was found to be associated with the development of early posttransplant complications.