An Effective Technology for the Development of Immediate Release Solid Dosage Forms Containing Low-Dose Drug: Fused Deposition Modeling 3D Printing


Gultekin H. E. , TORT S. , ACARTÜRK F.

PHARMACEUTICAL RESEARCH, vol.36, no.9, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 9
  • Publication Date: 2019
  • Doi Number: 10.1007/s11095-019-2655-y
  • Title of Journal : PHARMACEUTICAL RESEARCH

Abstract

Purpose Fabrication of immediate release (IR) tablet formulations with rapid release profile via fused deposition modeling 3D printing (FDM 3DP) is a challenge. The aims of this study were to prepare IR tablets with different dissolution profiles and to increase their in vitro dissolution rates by making physical modifications on them. Pramipexole was used as the model low-dose drug.