An Effective Technology for the Development of Immediate Release Solid Dosage Forms Containing Low-Dose Drug: Fused Deposition Modeling 3D Printing

Gultekin H. E., TORT S., ACARTÜRK F.

PHARMACEUTICAL RESEARCH, cilt.36, sa.9, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 9
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s11095-019-2655-y
  • Dergi Adı: PHARMACEUTICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: 3D printing, fused deposition modeling, hot melt extrusion, immediate release, personalized medicine, HOT-MELT EXTRUSION, TABLETS, FDM, FABRICATION, DELIVERY
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose Fabrication of immediate release (IR) tablet formulations with rapid release profile via fused deposition modeling 3D printing (FDM 3DP) is a challenge. The aims of this study were to prepare IR tablets with different dissolution profiles and to increase their in vitro dissolution rates by making physical modifications on them. Pramipexole was used as the model low-dose drug.