Sevoflurane and Isoflurane Preconditioning Provides Neuroprotection by Inhibition of Apoptosis-related mRNA Expression in a Rat Model of Focal Cerebral Ischemia

Bedirli N., Bağrıaçık E. Ü., Emmez H., Yilmaz G., Ünal Y., Özköse Şatırlar Z.

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, cilt.24, sa.4, ss.336-344, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/ana.0b013e318266791e
  • Dergi Adı: JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.336-344
  • Anahtar Kelimeler: sevoflurane, isoflurane, brain injury, CELL-DEATH, INHALATIONAL ANESTHETICS, POTASSIUM CHANNELS, BRAIN ISCHEMIA, STROKE, INJURY, PATHOPHYSIOLOGY, REPERFUSION, HALOTHANE, TOLERANCE
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: This study aimed to examine the effects of sevoflurane or isoflurane preconditioning on cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and lipid peroxidation and test the hypothesis that the underlining mechanism of the protective effect of preconditioning involves changes in the apoptotic gene expression profiles in an experimental model of middle cerebral artery occlusion in rats.