Sevoflurane and Isoflurane Preconditioning Provides Neuroprotection by Inhibition of Apoptosis-related mRNA Expression in a Rat Model of Focal Cerebral Ischemia

BEDİRLİ N., BAĞRIAÇIK E. Ü., Emmez H., Yilmaz G., ÜNAL Y., ÖZKÖSE ŞATIRLAR Z.

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, vol.24, no.4, pp.336-344, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1097/ana.0b013e318266791e
  • Journal Name: JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.336-344
  • Keywords: sevoflurane, isoflurane, brain injury, CELL-DEATH, INHALATIONAL ANESTHETICS, POTASSIUM CHANNELS, BRAIN ISCHEMIA, STROKE, INJURY, PATHOPHYSIOLOGY, REPERFUSION, HALOTHANE, TOLERANCE
  • Gazi University Affiliated: Yes

Abstract

Background: This study aimed to examine the effects of sevoflurane or isoflurane preconditioning on cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and lipid peroxidation and test the hypothesis that the underlining mechanism of the protective effect of preconditioning involves changes in the apoptotic gene expression profiles in an experimental model of middle cerebral artery occlusion in rats.