The main goal of this study was to evaluate knowledge of, perceptions of, and attitudes toward epilepsy and then to correlate knowledge with quality of life and stigmatization of children with epilepsy and their families. Specific questionnaires were administered to children aged 8 to 17 with epilepsy (n = 220) and their parents (n = 313). Poor school performance, less Social Support, less self-esteem, higher anxiety, greater stigmatization, and more depressive symptoms were documented in children who were less knowledgeable (P < 0.05). Parents were found to be more knowledgeable about the anti-epileptic drugs used, understanding both the effects and the side effects of the medications (P < 0.05). Family activities were less restricted if they were more knowledgeable and these parents reported worrying less about their children (P < 0.05). Knowledge about epilepsy is associated with less perceived stigmatization and social isolation, as well as fewer depressive symptoms and misperceptions. (C) 2008 Elsevier Inc. All rights reserved.