Lactobacillus plantarum and Lactobacillus helveticus modulate SIRT1, Caspase3 and Bcl-2 in the testes of high-fructose-fed rats

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Yildirim O. G., Sadi G., AKAR F.

ISTANBUL JOURNAL OF PHARMACY, cilt.50, sa.3, ss.168-175, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.26650/istanbuljpharm.2020.0076
  • Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.168-175
  • Anahtar Kelimeler: Dietary fructose, Lactobacillus plantarum, Lactobacillus helveticus, apoptosis, testes, INDUCED DIABETES INCREASES, INSULIN-RESISTANCE, OXIDATIVE STRESS, TESTICULAR DYSFUNCTION, METABOLIC SYNDROME, ZINC-DEFICIENCY, CELL APOPTOSIS, STREPTOZOTOCIN, RESVERATROL, ACTIVATION
  • Gazi Üniversitesi Adresli: Evet

Özet

Background and Aims: The influence of a high-fructose diet and probiotics on the mate reproductive system and the testicular apoptotic pathway has been poorly documented. In this study, we aimed to investigate the influence of Lactobacillus plantarum and Lactobacillus helveticus supplementation on apoptotic factors such as sirtuin1, caspase3 and bcl-2 on the testicular tissue of high-fructose-fed rats.