Allogeneic stem cell transplantation for severe aplastic anemia: Graft rejection remains a problem


Aki S. Z. , Sucak G. T. , ÖZKURT Z. N. , YEGİN Z. A. , Yagci M., Haznedar R.

TRANSFUSION AND APHERESIS SCIENCE, cilt.40, sa.1, ss.5-11, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 40 Konu: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.transci.2008.11.007
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Sayfa Sayıları: ss.5-11

Özet

We reviewed the outcome in 15 consecutive patients with severe aplastic anemia with a median age of 23 years who received matched sibling peripheral blood stein cell transplantation. Conditioning regimen was cyclophosphamide (Cy) + anti-thymocyte globulin (ATG). Cumulative incidence of transplant related mortality, graft failure, acute and chronic GVHD were 20%., 33%, 25%, and 8.3%, respectively. Conditioning with Cy only, resulted in higher rejection rate compared to Cy plus ATG (75%, versus 12.5%, p = 0.03). Eighty percent of patients are alive with a median follow-up of 19.5 (4.6-35.6) months. Two of the three patients who were re-transplanted with fludarabine had sustained donor chimerism. (C) 2008 Elsevier Ltd. All rights reserved.