Allogeneic stem cell transplantation for severe aplastic anemia: Graft rejection remains a problem

Aki S. Z., Sucak G. T., ÖZKURT Z. N., YEGİN Z. A., Yagci M., Haznedar R.

TRANSFUSION AND APHERESIS SCIENCE, cilt.40, sa.1, ss.5-11, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.transci.2008.11.007
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5-11
  • Anahtar Kelimeler: Severe aplastic anemia, Allogeneic stem cell transplantation, Rejection, Fludarabine, BONE-MARROW-TRANSPLANTATION, TERM-FOLLOW-UP, ANTITHYMOCYTE GLOBULIN, CONDITIONING REGIMEN, CYCLOPHOSPHAMIDE, FLUDARABINE, BLOOD, EXPERIENCE, FAILURE
  • Gazi Üniversitesi Adresli: Evet

Özet

We reviewed the outcome in 15 consecutive patients with severe aplastic anemia with a median age of 23 years who received matched sibling peripheral blood stein cell transplantation. Conditioning regimen was cyclophosphamide (Cy) + anti-thymocyte globulin (ATG). Cumulative incidence of transplant related mortality, graft failure, acute and chronic GVHD were 20%., 33%, 25%, and 8.3%, respectively. Conditioning with Cy only, resulted in higher rejection rate compared to Cy plus ATG (75%, versus 12.5%, p = 0.03). Eighty percent of patients are alive with a median follow-up of 19.5 (4.6-35.6) months. Two of the three patients who were re-transplanted with fludarabine had sustained donor chimerism. (C) 2008 Elsevier Ltd. All rights reserved.