Tezosentan attenuates organ injury and mesenteric blood flow decrease in endotoxemia and cecal ligation and puncture

ERDEM A., Sevgili A. M. , Akbiyik F., ATİLLA P., Cakar N., Balkanci Z. D. , ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.141, sa.2, ss.211-219, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 141 Konu: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.jss.2006.08.028
  • Sayfa Sayıları: ss.211-219


Background. Decreased mesenteric blood flow and multiple organ injury due to free radicals are the consequences of septic shock. Since the blockade of endothelin receptors was reported to exert beneficial effects, we investigated the effects of tezosentan, a novel dual endothelin receptor antagonist, in two different experimental models of septic shock induced either by the injection of Escherichia coli endotoxin (ETX, 20 mg/kg, i.p.) or by cecal ligation and puncture (CLP).