Implementation of the European multicentre database of healthy controls for [I-123]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

Albert, Nathalie; Unterrainer, Marcus; Diemling, Markus; Xiong, Guoming; Bartenstein, Peter; Koch, Walter; Varrone, Andrea; Dickson, John; Tossici-Bolt, Livia; Sera, Terez; Asenbaum, Susanne; Booij, Jan; Kapucu, LÜTFİYE; Kluge, Andreas; Ziebell, Morten; Darcourt, Jacques; Nobili, Flavio; Pagani, Marco; Sabri, Osama; Hesse, Swen; Vander Borght, Thierry; Van Laere, Koen; Tatsch, Klaus; la Fougere, Christian

doi:10.1007/s00259-015-3304-2

Implementation of the European multicentre database of healthy controls for [I-123]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

Atıf İçin Kopyala

Albert N. L., Unterrainer M., Diemling M., Xiong G., Bartenstein P., Koch W., ...Daha Fazla

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, cilt.43, sa.7, ss.1315-1322, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 43 Sayı: 7
Basım Tarihi: 2016
Doi Numarası: 10.1007/s00259-015-3304-2
Dergi Adı: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1315-1322
Anahtar Kelimeler: Diagnostic accuracy, EARL-BRASS, [I-123] FP-CIT SPECT, Parkinsonian syndromes, DOPAMINE TRANSPORTER BINDING, DISEASE, AGE, I-123-IOFLUPANE, DIFFERENTIATION, I-123-FP-CIT, GENDER, TREMOR, BRAIN
Gazi Üniversitesi Adresli: Evet

Özet

Purpose Even though [I-123]FP-CIT SPECT provides high accuracy in detecting nigrostriatal cell loss in neurodegenerative parkinsonian syndromes (PS), some patients with an inconclusive diagnosis remain. We investigated whether the diagnostic accuracy in patients with clinically uncertain PS with previously inconclusive findings can be improved by the use of iterative reconstruction algorithms and an improved semiquantitative evaluation which additionally implemented a correction algorithm for patient age and gamma camera dependency (EARL-BRASS; Hermes Medical Solutions, Sweden).