Akademik Veri Yönetim Sistemi
Gazi Medical Journal, cilt.13, sa.3, ss.109-112, 2002 (Scopus)
Purpose: In recent years, it has been suggested that insulin resistance (IR) might be an initializing and /or contributing factor for the polycystic ovary syndrome (PCOS). Many studies reported that arteriosclerosis is a coexisting pathology in PCOS probably due to existing IR. The aim of the study was to investigate the degree of IR and lipid profile in patients with PCOS. Methods: Sixty-four patients with PCOS (mean age: 23.04±5.5) and 21 healthy controls (mean age: 27.31±8.3) were included in the study. Physical examination, routine biochemical analysis, ovary and adrenal gland hormone assays and abdomen and pelvic ultrasonography were performed in all cases. Peripheral IR was investigated by euglycemic-hyperinsulinemic clamp test (EHCT) in both groups. Results: Waist-to-hip ratio (WHR), luteinizing hormone (LH), LH/ follicular stimulating hormone (FSH) ratio, free testosterone (FT) and androstenedione (A) levels were higher, whereas sex hormone-binding globulin (SHBG) and FSH levels were lower in PCOS group than the control group (p<0.05). In 73.4% of patients oligohypomenorrhea and 12.5% of patients high prolactin (PRL) levels were obtained. Ovary volumes were significantly increased in patients with PCOS. Severe IR was detected in 19.3%, and mild IR in remainder of the PCOS group. As IR increased, an increase in low-density lipoprotein cholesterol (LDL-C) and a decrease in high-density lipoprotein (HDL-C) levels were obtained in patients with PCOS. Conclusion: In the presence of IR, increased levels of LDL-C and decreased levels of HDL-C may play a role in early arteriosclerosis in patients with PCOS.