Akademik Veri Yönetim Sistemi
37th European Congress of Pathology, Vienna, Avusturya, 6 - 10 Eylül 2025, cilt.487, ss.1-563, (Özet Bildiri)
E-PS-13-055
Calcifying odontogenic cyst: a case series and literature review
A.H. Üstündağ¹, B. Toközlü¹
¹ Gazi University, Department of Oral Pathology, Ankara, Turkey
Background & Objectives: The calcifying odontogenic cyst (COC) is an uncommon, benign developmental cyst derived from odontogenic epithelium, characterized by its potential to undergo calcification and accounting for approximately 0.3–0.8% of all odontogenic cysts. The aim of the study was evaluating clinical and pathologic characteristics of a case series of COC.
Methods: This study reports an 11-year (2014–2025) case series from our oral pathology department, comprising a total of 15 cases of COCs. Demographic data and histopathological diagnoses were evaluated descriptively. Additionally, a literature review of case series was conducted using PubMed.
Results: The average patient age was 36 years (range: 13–70), with 8 males and 7 females. The cysts were most frequently located in the posterior mandible, followed by the anterior maxilla, anterior mandible, and posterior maxilla. Clinically, most cases were asymptomatic, while a few presented with swelling or tooth mobility. Radiologically, all lesions appeared as well-defined, unilocular radiolucencies with an average size of 1.5 cm. Histologically, ghost cells, dystrophic calcifications, reverse polarization, and remnants of odontogenic epithelium were commonly observed. In two cases, palisaded, hyperchromatic ameloblast-like cells were noted. Notably, one case was a hybrid lesion exhibiting features of both a calcifying odontogenic cyst and an adenomatoid odontogenic tumour, with epithelial cells forming rosette- and duct-like structures within a hyalinized matrix.
Conclusion: COC is a rare developmental odontogenic cyst with a historically debated nature. It can present with a variety of clinical features and outcomes, appearing as a solid tumour, a unilocular cystic lesion, or, in rare cases, as a carcinoma. The distinguishing feature is the odontogenic cystic epithelium, which may include calcifications and ghost cells. In the differential diagnosis, it is important to distinguish it from dentinogenic ghost cell tumour and ghost cell odontogenic carcinoma.