Akademik Veri Yönetim Sistemi
Gazi Medical Journal, cilt.14, sa.3, ss.97-102, 2003 (Scopus)
Purpose: To investigate the effect of epidermal growth factor (EGF) dosage form prepared in polyethylene glycol 4000 (PEG) on titanium implanted oral wounds. Methods: Five-month-old New Zealand rabbits were divided into three groups (n=10): in the first group a titanium ring was implanted in the oral mucosa by incision, in the second group a titanium (Ti) ring was implanted together with EGF, and in the third group a titanium ring was implanted with EGF (40 ng) dosage form in PEG. All groups' incision wounds were closed with two stitches. At the end of the fifth day wound healing was examined histologically and by means of wound tear strengths, and the hydroxyproline content of wound edges. Results: The wound tissue tear strength value of the PEG+EGF + Ti group was higher than both that of the PEG+ Ti group (P<0.05) and that of the Ti group (P<0.01). The hydroxyproline level of wound tissue in the PEG+EGF+ Ti group was higher than that in the other groups. A histologic examination of the wounds revealed that epithelial growth differed between groups. One layer of epithelium was observed in the PEG+ Ti groups' wound tissues. It was noteworthy that the epithelia were multilayer and smooth in the PEG+EGF+ Ti groups' wounds. Conclusion: The results suggest that EGF application in polyethylene glycol to dental titanium implants augments oral mucosal incision wound healing.