Research on the radioprotective effects of calcium antagonists on the jejunal mucosa of Swiss albino mice

Bora H., Akmansu M., Sonal S., Ozturk B.

BIOCHEMICAL ARCHIVES, cilt.15, sa.3, ss.247-250, 1999 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 1999
  • Dergi Adı: BIOCHEMICAL ARCHIVES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.247-250
  • Gazi Üniversitesi Adresli: Evet

Özet

in this study it was sought whether or not calcium antagonists had a radioprotective effect on the mouse small bowel.. Swiss albino mice, each weighting 20-25 grams were used in this study. These mice were separate into four groups in which each group was composed of 10 animals. Twenty minutes before 9 Gy total body irradiation, an intraperitoneal administration of 0.1cc/10 gr of 0.9% NaCl to the 1(st) group, 110mg/kg diltiazem to the 2(nd) group, 3mg/kg nifedipine to the 3(rd) group and 16mg/kg verapamil were performed to the 4(th) group. Three days after the irradiation the animals were decapitated and the jejunal damage was evaluated microscopically by counting the crypts per circumference and by grading the histologic damage. The average crypt number and histologic scores in groups receiving a calcium antagonist was not significantly different than that of the control group (p> 0.05). In this study it was concluded that Ca antagonists had no protective effect on small intestines of mice from acute irradiation.