Leptospirosis is a zoonotic infectious disease that can involve many organs and it has variable manifestations. In this paper, we describe epitrochlear lymph node involvement as an isolated finding in a case of anicteric leptospirosis, that, to our knowledge, has not been previously reported. The lymph node was excised and light microscopy showed enlarged secondary follicles with prominent germinal centers, some with bizarre shapes along with an increase in high endothelial venules. A Warthin-Starry stain revealed spirochetal organisms which were cork-screw shaped with hooked ends. Serology for leptospira confirmed this bacterium as the etiology of the reactive lymphadenopathy while tests for syphilis and borreliosis were negative.