Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets

Takka S., Rajbhandari S., Sakr A.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol.52, no.1, pp.75-82, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 1
  • Publication Date: 2001
  • Doi Number: 10.1016/s0939-6411(01)00147-3
  • Journal Name: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.75-82
  • Keywords: hydroxypropylmethylcellulose, methacrylic acid copolymers, sodium carboxymethylcellulose, matrix tablets, pH-independent release, DRUG-RELEASE, HYDROXYPROPYLMETHYLCELLULOSE MATRICES, DISSOLUTION, GELS, METHYLCELLULOSE, MECHANISMS, DIFFUSION, DELIVERY, RESINS
  • Gazi University Affiliated: Yes

Abstract

Anionic polymers, namely Eudragit S, Eudragit L 100-55, and sodium carboxymethylcellulose, were incorporated into hydroxypropylmethylcellulose (HPMC K100M) to modify the drug release from HPMC matrices. The effects of changing the ratio of HPMC to anionic polymers were examined in water and in media with different pH. The dissolution profiles were compared according to release rates. The interaction between propranolol hydrochloride and anionic polymers was confirmed using the UV difference spectra method. The drug release was controlled with the type of anionic polymer and the interaction between propranolol hydrochloride and anionic polymers. The HPMC-anionic polymer ratio also influenced the drug release. The matrix containing HPMC-Eudragit L 100-55 (1:1 ratio) produced pH-independent extended-release tablets in water, 0.1 N HCl, and pH 6.8 phosphate buffer. (C) 2001 Elsevier Science B.V. All rights reserved.