Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus

Gursoy, Ibrahim; BARUN, SÜREYYA; Erdem, Remzi; KESKİN, ULYA; Kiziltas, Murat; ATİLLA, PERGİN; Muftuoglu, Sevda; YÜCE, DENİZ; Narin, Firat; Ertunc, Mert; Sara, Yildirim; CANPINAR, HANDE

doi:10.5137/1019-5149.jtn.27023-19.3

Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus

Gursoy I. D., BARUN S., Erdem R., KESKİN U., Kiziltas M., ATİLLA P., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.30, sa.6, ss.871-884, 2020 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 30 Sayı: 6
Basım Tarihi: 2020
Doi Numarası: 10.5137/1019-5149.jtn.27023-19.3
Dergi Adı: TURKISH NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.871-884
Anahtar Kelimeler: Status epilepticus, Electroconvulsive seizure, Ketamine, Dantrolene, Cognition, Rats, METHYL-D-ASPARTATE, CELL-DEATH, ENDOPLASMIC-RETICULUM, RECEPTOR HYPOFUNCTION, SYNAPTIC PLASTICITY, GABAERGIC NEURONS, MEMORY IMPAIRMENT, SELECTIVE LOSS, DENTATE GYRUS, KAINIC ACID
Gazi Üniversitesi Adresli: Evet

Özet

AIM: To evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in rats exposed to repeated electroconvulsive seizures (ECS) as a model of status epilepticus (SE).