Effect of sumatriptan following simulated traumatic brain injury in rats Účinek sumatriptanu po simulovaném traumatickém poranění mozku u potkanů


Bozkurt I., Senturk S., YAMAN M., Guvenc Y., Ozturk Y., Guney G., ...Daha Fazla

Ceska a Slovenska Neurologie a Neurochirurgie, cilt.85, sa.5, ss.389-396, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 85 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.48095/cccsnn2022389
  • Dergi Adı: Ceska a Slovenska Neurologie a Neurochirurgie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE
  • Sayfa Sayıları: ss.389-396
  • Anahtar Kelimeler: sumatriptan, trauma, brain injury, neuroprotective, anti-inflammatory, anti-oxidative, NEURON-SPECIFIC ENOLASE, NITRIC-OXIDE, MODEL, PROTEIN
  • Gazi Üniversitesi Adresli: Evet

Özet

© 2022, Czech Medical Association J.E. Purkyne. All rights reserved.Introduction: Traumatic brain injury (TBI) continues to be a devastating problem in developing countries. The inevitable traumatic effect is followed by a secondary phase of neuroinflammation leading to increased morbidity and mortality. Numerous agents and treatment modalities have been tested to date. The first clinically available triptan used to treat migraine, sumatriptan (SUM), has been evaluated for cerebral, testicular and renal ischemia previously but to our knowledge this is the first paper where its anti-inflammatory and anti-oxidative effects after experimental TBI in rats has been evaluated. Aim: Employing an experimental trauma technique, we aimed to investigate whether SUM has ameliorating effects on the inflammatory phase of TBI via neurological, histological and biochemical analyses. Methodology: Twenty-three Wistar albino rats were randomly divided into three groups: control, trauma and trauma + SUM. The two latter groups underwent experimental diffuse cortical injury mimicking TBI. The subjects underwent neurological assessment via the Garcia Test, histological analysis via a novel scoring system and biochemical analyses of neuron specific enolase (NSE), S-100B, caspase-3 (CASP3), and rat thiobarbituric acid reactive substances (TBARS) levels. Results: SUM receiving group had a better Garcia Test score (P < 0.001), higher anti-inflammatory score (P = 0.004) and higher neuroprotective score (P < 0.001) along with a better histopathological score when compared with the trauma group. SUM receiving group had lower levels of S100B, CASP3 and TBARS. SUM was unable to reduce NSE levels. Conclusion: SUM may prove to be beneficial in decreasing mortality and morbidity rates after TBI through its anti-inflammatory and anti-oxidative effects. The novel scoring system used in this study may be a valuable tool for similar experiments.