Iron Overload in the Liver of 2 Children: Nonalcoholic Steatohepatitis and Juvenile Hemochromatosis

Aksu A. U., Caleffi A., Pietrangelo A., SARI S., EĞRİTAŞ GÜRKAN Ö., Demirtas Z., ...More

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.39, no.6, pp.466-469, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1097/mph.0000000000000752
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.466-469
  • Keywords: iron overload, nonalcoholic steatohepatitis, juvenile hemochromatosis, phlebotomy, MANAGEMENT, HEPCIDIN
  • Gazi University Affiliated: Yes

Abstract

Background:Iron overload disorders are hereditary hemochromatosis and secondary etiologies other than hereditary hemochromatosis. We describe 2 boys presenting with iron overload. Juvenile hemochromatosis and nonalcoholic steatohepatitis (NASH) related iron overload are the genetic and secondary causes, respectively.Observations:Both patients benefited from phlebotomy even if they had different etiologies.Conclusions:In childhood, the diagnosis of iron overload syndromes is crucial because they do not confront us with obvious symptoms and findings. Early initiation of a phlebotomy program can prevent mortality. NASH might lead to iron overload and iron overload might aggravate the clinical course of NASH.