Malignant pleural mesothelioma with scalp, cerebellar, and finger metastases: a rare case.

Kanbay A., Oguzulgen K. I. , Ozturk C., Memis L., Demircan S., Kurkcuoglu C., ...More

Southern medical journal, vol.100, no.1, pp.63-5, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 100 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1097/smj.0b013e31802e465c
  • Journal Name: Southern medical journal
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.63-5
  • Keywords: mesothelioma, distant metastases, CUTANEOUS METASTASIS, TONGUE


Malignant pleural mesothelioma (MPM) is a rare and asbestosis-associated tumor. MPM commonly invades locally, mostly in the lung, heart, pericardium, chest wall, and vertebrae. Distant metastasis of MPM is very rare. Here we report a patient with MPM who presented with multiple unusual distant metastases. The patient's thorax tomography demonstrated right-sided, irregularly-thickened pleura with nodular masses and invasion of the chest wall into the subcutaneous area. The patient underwent biopsy for a subcutaneous mass in the right anterior chest wall. Pathologic examination revealed a malignant mesenchymal tumor. During follow-up, he suffered from a painful nodule on the scalp and nodules on the fingers, as well as weakness in his right ann. Cranial magnetic resonance imaging illustrated a 1 cm nodule in the left cerebellar hemisphere. Histopathologic examination of the biopsy from the nodule on the scalp revealed a typical mixed type of MPM, with calretinin, vimentin and creatine 5/6 positivity. Distant metastases can be seen in MPM and a biopsy of metastatic regions can yield the diagnosis.