A rare case of coronin-1A deficiency with IgM dominant membranoproliferative glomerulonephritis

Ural Z., ÖĞÜT B., KAYHAN G., IŞIK GÖNÜL İ., DERİCİ Ü.

CEN CASE REPORTS, vol.14, no.5, pp.687-692, 2025 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 5
  • Publication Date: 2025
  • Doi Number: 10.1007/s13730-025-01004-2
  • Journal Name: CEN CASE REPORTS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.687-692
  • Keywords: Coronin-1A deficiency, Immunodeficiency, Membranoproliferative glomerulonephritis
  • Gazi University Affiliated: Yes

Abstract

Coronin-1A deficiency, caused by mutations in the CORO1A gene, is an autosomal recessive immunodeficiency characterized by T-cell dysfunction and is classified as severe combined immunodeficiency (SCID). This condition presents with lymphopenia, hypogammaglobulinemia, recurrent Epstein-Barr virus (EBV) infections, EBV-associated B-cell lymphoma and epidermodysplasia verruciformis. This case report presents a 32-year-old female with Coronin-1A deficiency, who developed IgM-dominant membranoproliferative glomerulonephritis (MPGN) alongside recurrent viral infections. This is the first reported case linking Coronin-1A deficiency with MPGN. The patient was treated with corticosteroids, which improved her renal function, but she succumbed to recurrent infections within a year. This case emphasizes the potential for renal disease in immunodeficient patients with persistent infections.