Thermal comfort is one of the most important physical risks encountered in work systems. In addition to the seasonal temperatures, especially in the summer months, the rising temperature in the work environment negatively affect the productivity of the employees. The applicability of the climatic precautions to be taken to provide thermal comfort for the employees in production environments may not be possible due to required quality characteristics of the products or economic reasons. In this case, protecting employees from heat stress and heat stress-related diseases is only possible with certain administrative measures. One of the quick and effective administrative measures that can be taken in this sense will be the rotation of employees among duties and the distribution of risks that may arise thermally among employees. In this study, a mixed-integer mathematical model, which considers both the thermal conditions of the employees and the classical economic issues about the company simultaneously, was proposed. Taking into account the metabolic rate equal values of the duties while ensuring the thermal comfort parameter enabled the protection of the employees in terms of both parameters.