Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and long-wave ultraviolet radiation.

SARDAS S., KARAHALIL B., KARAKAYA A., SASMAZ R.

Mutation research, cilt.312, sa.2, ss.79-83, 1994 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 312 Sayı: 2
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0165-1161(94)90012-4
  • Dergi Adı: Mutation research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.79-83
  • Gazi Üniversitesi Adresli: Evet

Özet

Sister-chromatid exchange (SCE) analysis was carried out in different age groups prior to and after therapy with 8-Methoxypsoralen (8-MOP) followed by exposure of the patient to long-wave UV-A (PUVA) and compared to control. The SCE frequencies were increased significantly in PUVA-treated patients as compared to their pre-treatment SCE levels and to controls. A significant increase in SCEs was found in smoking PUVA-treated patients as compared to non-smoking PUVA-treated patients. This study indicates a detectable chromosome-damaging effect of PUVA therapy on its human users.