Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and long-wave ultraviolet radiation.


SARDAS S., KARAHALIL B. , KARAKAYA A., SASMAZ R.

Mutation research, cilt.312, ss.79-83, 1994 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 312 Konu: 2
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0165-1161(94)90012-4
  • Dergi Adı: Mutation research
  • Sayfa Sayıları: ss.79-83

Özet

Sister-chromatid exchange (SCE) analysis was carried out in different age groups prior to and after therapy with 8-Methoxypsoralen (8-MOP) followed by exposure of the patient to long-wave UV-A (PUVA) and compared to control. The SCE frequencies were increased significantly in PUVA-treated patients as compared to their pre-treatment SCE levels and to controls. A significant increase in SCEs was found in smoking PUVA-treated patients as compared to non-smoking PUVA-treated patients. This study indicates a detectable chromosome-damaging effect of PUVA therapy on its human users.