Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and long-wave ultraviolet radiation.


SARDAS S., KARAHALIL B., KARAKAYA A., SASMAZ R.

Mutation research, vol.312, no.2, pp.79-83, 1994 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 312 Issue: 2
  • Publication Date: 1994
  • Doi Number: 10.1016/0165-1161(94)90012-4
  • Journal Name: Mutation research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.79-83
  • Gazi University Affiliated: Yes

Abstract

Sister-chromatid exchange (SCE) analysis was carried out in different age groups prior to and after therapy with 8-Methoxypsoralen (8-MOP) followed by exposure of the patient to long-wave UV-A (PUVA) and compared to control. The SCE frequencies were increased significantly in PUVA-treated patients as compared to their pre-treatment SCE levels and to controls. A significant increase in SCEs was found in smoking PUVA-treated patients as compared to non-smoking PUVA-treated patients. This study indicates a detectable chromosome-damaging effect of PUVA therapy on its human users.