Does Switching to Another Antipsychotic in Patients With Clozapine-Associated Granulocytopenia Solve the Problem? Case Series of 18 Patients

COŞAR B., TANER M. E., Eser H. Y., ALTINÖZ A. E., Tarhan R.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, cilt.31, sa.2, ss.169-173, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1097/jcp.0b013e31820e3d9d
  • Dergi Adı: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.169-173
  • Anahtar Kelimeler: clozapine, agranulocytosis, prolongation, schizophrenia, olanzapine, quetiapine, antipsychotic, OLANZAPINE-INDUCED NEUTROPENIA, RISPERIDONE-INDUCED LEUKOPENIA, INDUCED AGRANULOCYTOSIS, REVERSIBLE NEUTROPENIA, PROLONGATION, SAFE
  • Gazi Üniversitesi Adresli: Evet

Özet

Clozapine is a well-known drug that is used in treatment-resistant schizophrenia, but granulocytopenia, which may lead to a potentially fatal condition such as agranulocytosis, limit its use. The question about which antipsychotic should be used after a diagnosis of clozapine-associated granulocytopenia is difficult to answer, because antipsychotics other than clozapine may also have hematologic toxicity, or they may prolong clozapine-associated granulocytopenia. In this study, we aimed to find out the incidence of clozapine-associated granulocytopenia in our treatment sample and discuss suitable antipsychotic drug options in terms of hematologic toxicity, for management of clozapine-associated granulocytopenia.