Sulphasalazine treatment in protracted familial Mediterranean fever arthritis

BAKKALOĞLU EZGÜ S. A., AKSU T., GÖKER B., Unlusoy A., Peru H., Fidan K., ...More

EUROPEAN JOURNAL OF PEDIATRICS, vol.168, no.8, pp.1017-1019, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 168 Issue: 8
  • Publication Date: 2009
  • Doi Number: 10.1007/s00431-008-0875-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1017-1019
  • Keywords: Familial Mediterranean fever, Arthritis, Sulphasalazine, INTERFERON-ALPHA, ETANERCEPT, PATIENT
  • Gazi University Affiliated: Yes


Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited attacks of fever and polyserositis. Articular involvement in early-onset FMF is a common finding characterized by non-erosive, generally asymmetric monoarthritis in large joints. Protracted FMF arthritis was reported in 2.6% of Turkish patients. An 8-year-old female who has a history of FMF for 5 years applied to our hospital with complaints of persistent swelling and pain of her left knee for 8 months. The patient had been tried to be managed with non-steroidal anti-inflammatory drugs as well as intra-articulary steroids and colchicine. However, arthritis and acute phase response persisted. With sulphasalazine, complete recovery was achieved. It is our belief that sulphasalazine can be a choice of medical treatment in protracted FMF arthritis.