Copy For Citation
Emerce E., Çok İ., Degim I. T.
TOXICOLOGY LETTERS, vol.238, no.2, pp.90-99, 2015 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
238
Issue:
2
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Publication Date:
2015
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Doi Number:
10.1016/j.toxlet.2015.07.003
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Journal Name:
TOXICOLOGY LETTERS
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.90-99
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Keywords:
Genotoxic impurities, (Q)SAR analysis, Ames test, Chromosomal aberration test, Hplc, Regulations, MICROTITRE FLUCTUATION TEST, IN-SILICO, GENOTOXICITY EVALUATION, PHARMACEUTICAL QUALITY, MUTAGENICITY, ASSAY, IDENTIFICATION, LEVOFLOXACIN, SENSITIVITY, VALIDATION
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Gazi University Affiliated:
Yes
Abstract
Impurities affecting safety, efficacy, and quality of pharmaceuticals are of increasing concern for regulatory agencies and pharmaceutical industries, since genotoxic impurities are understood to play important role in carcinogenesis. The study aimed to analyse impurities of montelukast chronically used in asthma theraphy and perform genotoxicological assessment considering regulatory approaches.