Cloning and expression profile of FLT3 gene during progenitor cell-dependent liver regeneration

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Aydin I. T., Tokcaer Z., Dalgic A., Konu O., Akcali K. C.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.22, sa.12, ss.2181-2188, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 12
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1440-1746.2006.04731.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2181-2188
  • Anahtar Kelimeler: cloning, FLT3, liver regeneration, rat, HEPATIC STEM-CELLS, BONE-MARROW CELLS, OVAL CELLS, PARTIAL-HEPATECTOMY, RESECTION, ORIGIN
  • Gazi Üniversitesi Adresli: Hayır

Özet

Background and Aim: The liver has a unique capacity to regenerate upon exposure to viral infections, toxic reactions and cancer formation. Liver regeneration is a complex phenomenon in which several factors participate during its onset. Cellular proliferation is an important component of this process and the factors that regulate this proliferation have a vital role. FLT3, a well-known hematopoietic stem cell and hepatic lineage surface marker, is involved in proliferative events of hematopoietic stem cells. However, its contribution to liver regeneration is not known. Therefore, the aim of this study was to clone and examine the role of FLT3 during liver regeneration in rats.