Cloning and expression profile of FLT3 gene during progenitor cell-dependent liver regeneration


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Aydin I. T. , Tokcaer Z., Dalgic A., Konu O., Akcali K. C.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.22, no.12, pp.2181-2188, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 12
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1440-1746.2006.04731.x
  • Title of Journal : JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Page Numbers: pp.2181-2188

Abstract

Background and Aim: The liver has a unique capacity to regenerate upon exposure to viral infections, toxic reactions and cancer formation. Liver regeneration is a complex phenomenon in which several factors participate during its onset. Cellular proliferation is an important component of this process and the factors that regulate this proliferation have a vital role. FLT3, a well-known hematopoietic stem cell and hepatic lineage surface marker, is involved in proliferative events of hematopoietic stem cells. However, its contribution to liver regeneration is not known. Therefore, the aim of this study was to clone and examine the role of FLT3 during liver regeneration in rats.