Studies on the synthesis of 3-methyl-6-(substituted-urea/-thiourea)-2(3H)-benzothiazolone derivatives and antimicrobial activities
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, cilt.54, sa.2, ss.253-259, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 54 Sayı: 2
- Basım Tarihi: 2015
- Dergi Adı: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.253-259
- Anahtar Kelimeler: 2(3H)-Benzothiazolone, urea, thiourea, antimicrobial, antitubercular activity, BIOLOGICAL EVALUATION, THIOUREA, UREA, TUBERCULOSIS, RESISTANCE, AGENTS
- Gazi Üniversitesi Adresli: Evet
Özet
A series of sixteen new urea and thiourea derivatives at position 6 of 3-methyl-2(3H)-benzothiazolone ring have been prepared and studied using 1R, H-1 NMR, mass spectra and elemental analysis. The urea and thiourea derivatives have been obtained by the reaction of 6-amino-3-methyl-2(3H)-benzothiazolone with appropriate isocyanates and isothiocyanates. The antibacterial, antifungal and antimycobacterial activities of the synthesized compounds have been evaluated in vitro using microdilution and microplate methods.