Studies on the synthesis of 3-methyl-6-(substituted-urea/-thiourea)-2(3H)-benzothiazolone derivatives and antimicrobial activities


Unal A. S., KAYNAK ONURDAĞ F., Ozgen S., DOĞRUER D. S., ÖNKOL T.

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol.54, no.2, pp.253-259, 2015 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 2
  • Publication Date: 2015
  • Journal Name: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.253-259
  • Keywords: 2(3H)-Benzothiazolone, urea, thiourea, antimicrobial, antitubercular activity, BIOLOGICAL EVALUATION, THIOUREA, UREA, TUBERCULOSIS, RESISTANCE, AGENTS
  • Gazi University Affiliated: Yes

Abstract

A series of sixteen new urea and thiourea derivatives at position 6 of 3-methyl-2(3H)-benzothiazolone ring have been prepared and studied using 1R, H-1 NMR, mass spectra and elemental analysis. The urea and thiourea derivatives have been obtained by the reaction of 6-amino-3-methyl-2(3H)-benzothiazolone with appropriate isocyanates and isothiocyanates. The antibacterial, antifungal and antimycobacterial activities of the synthesized compounds have been evaluated in vitro using microdilution and microplate methods.