The detrimental effects of diabetes on pluripotency determined by KLF4, SOX2, C-MYC and OCT4 immunoreactivity in rat testes.


Aktug H., Uysal A., Yavasoglu A., Oltulu F., Akarca S. Ö. , Yilmaz-Dilsiz O., ...More

Advances in clinical and experimental medicine : official organ Wroclaw Medical University, vol.22, pp.327-35, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2013
  • Journal Name: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.327-35
  • Keywords: Klf4 protein, SOX2, c-Myc transcription factor, Oct4 protein, rat, testes, diabetes mellitus, experimental, SERTOLI-CELLS, GERM-CELLS, POU-DOMAIN, STEM-CELLS, GENE, PROTEIN, EXPRESSION, FERTILITY, EMBRYO, P53
  • Gazi University Affiliated: Yes

Abstract

Background. Diabetes mellitus (DM) is a multisystem disorder. Type 1 DM can be experimentally induced in rats with streptozotocin (STZ). Diabetic conditions result in testicular oxidative stress and suppressed male reproductive activity as well as decreases in both testicular organ weights and subject weights.