The detrimental effects of diabetes on pluripotency determined by KLF4, SOX2, C-MYC and OCT4 immunoreactivity in rat testes.

Aktug H., Uysal A., Yavasoglu A., Oltulu F., Akarca S. Ö., Yilmaz-Dilsiz O., ...Daha Fazla

Advances in clinical and experimental medicine : official organ Wroclaw Medical University, cilt.22, ss.327-35, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22
  • Basım Tarihi: 2013
  • Dergi Adı: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.327-35
  • Anahtar Kelimeler: Klf4 protein, SOX2, c-Myc transcription factor, Oct4 protein, rat, testes, diabetes mellitus, experimental, SERTOLI-CELLS, GERM-CELLS, POU-DOMAIN, STEM-CELLS, GENE, PROTEIN, EXPRESSION, FERTILITY, EMBRYO, P53
  • Gazi Üniversitesi Adresli: Evet

Özet

Background. Diabetes mellitus (DM) is a multisystem disorder. Type 1 DM can be experimentally induced in rats with streptozotocin (STZ). Diabetic conditions result in testicular oxidative stress and suppressed male reproductive activity as well as decreases in both testicular organ weights and subject weights.