Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents

Ertan T., Yildiz I., Ozkan S., Temiz-Arpaci O., Kaynak F., Yalcin I., ...Daha Fazla

BIOORGANIC & MEDICINAL CHEMISTRY, cilt.15, sa.5, ss.2032-2044, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.bmc.2006.12.035
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2032-2044
  • Anahtar Kelimeler: antibacterial activity, antifungal activity, benzamide, phenylacetamide, MICROBIOLOGICAL ACTIVITY, POSSIBLE METABOLITES, RESISTANCE
  • Gazi Üniversitesi Adresli: Hayır

Özet

A new series of N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamide and phenylacetamide derivatives (la-In, 2a-2n) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and their drug-resistant isolates. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 500 and 1.95 mu g/ml. Benzamide derivative Id exhibited the greatest activity with MIC values of 1.95, 3.9, and 7.8 mu g/ml against drug-resistant B. subtilis, B. subtilis, and S. aureus, respectively. (c) 2007 Elsevier Ltd. All rights reserved.