Oxcarbazepine does not suppress cortical spreading depression

Hoffmann U., Dilekoez E., Kudo C., Ayata C.

CEPHALALGIA, cilt.31, sa.5, ss.537-542, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/0333102410388433
  • Dergi Adı: CEPHALALGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.537-542
  • Anahtar Kelimeler: Cortical spreading depression, migraine, oxcarbazepine, valproate, MIGRAINE PROPHYLAXIS, NEUROPATHIC PAIN, RAT, CARBAMAZEPINE, VALPROATE, DAMAGE, MODEL
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Cortical spreading depression is the electrophysiological substrate of migraine aura, and may trigger headache. Recently, chronic treatment with five migraine prophylactic drugs was shown to suppress cortical spreading depression, implicating spreading depression as a common therapeutic target in migraine prophylaxis.