The synthesis of novel methotrexate-like compounds

Colak N., Yildirir Y., Kavutcu M., Nurlu N.

MONATSHEFTE FUR CHEMIE, cilt.138, sa.12, ss.1283-1287, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 138 Sayı: 12
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00706-007-0716-0
  • Dergi Adı: MONATSHEFTE FUR CHEMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1283-1287
  • Gazi Üniversitesi Adresli: Evet

Özet

Methotrexate (MTX) is a folate antagonist used in treatment of several chronic inflammatory and neoplastic conditions. In this study, new MTX-like compounds that may-be potential anticancer agents were synthesized and their structures were determined by IR, UV, GC-MS, H-1 NMR, and C-13 NMR spectra. Also, in this study, a series structurally related to MTX or folate analogous compounds were evaluated whether they have inhibitory properties on the dihydrofolate reductase activity (DHFR).