Akademik Veri Yönetim Sistemi
JOURNAL OF NEUROLOGICAL AND ORTHOPAEDIC MEDICINE AND SURGERY, cilt.17, sa.2, ss.87-94, 1996 (SCI-Expanded)
1-B-D Arabinofuranosylcytosine (cytosine arabinoside, Ara-C) is an inhibitor of DNA synthesis used in treatment of breast carcinoma, acute lymphocytic leukemia (ALL) and acute myelocytic leukemia (AML). When Ara-C was administered to the mouse by intraperitoneal injection on the 11(th) gestational day with a single dose of 10 mg/kg/day, it caused significant skeletal anomalies in the fetuses. Especially the fetal weights decreased significantly. Similarly, oligodactyly in forelimbs, snydactyly in hindlimbs, absence of ossification centers in the skull and extremity bones were also common effects. Other anomalies were oligodactyly in hindlimbs, tail anomalies, syndactyly in forelimbs, phalangeal hypoplasia, shortness or absence of fingers, abnormal angulation in hand and foot digits. On the basis of such observations, administration of Ara-C in the critical period of pregnancy is considered to be risky.