Antioxidant enzymes and diabetic retinopathy

Yildirim Z., Ucgun N. I., Kilic N., Guersel E., Sepici-Dincel A.

BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS, cilt.1100, ss.199-201, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1100
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1196/annals.1395.019
  • Dergi Adı: BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.199-201
  • Anahtar Kelimeler: copper, zinc, superoxide dismutase, nitric oxide, glutathione, advanced oxidation protein products, diabetic retinopatyv, OXIDATIVE STRESS, FREE-RADICALS, NITRIC-OXIDE, PRODUCTS
  • Gazi Üniversitesi Adresli: Hayır

Özet

The aim of this study was to discuss the serum copper (Cu), zinc (Zn), nitric oxide (NO), glutathione (GSH), advanced oxidation protein products (AOPP) levels, and superoxide dismutase (SOD) activities with diabetic retinopathy severity. Twenty-five patients with proliferative diabetic retinopathy (PDR group 1), 25 patients with nonproliferative diabetic retinopathy (NPDR group 2), and 25 nondiabetic controls (control group) were included in the study. Patients who had macrovascular complications of diabetes (coronary arterial disease, periferic vascular disease) were excluded. The major finding of our study was that we did not observe any differences between group 1 and 2, which we aimed to discuss the severity of diabetic retinopathy. As the levels of SOD and Zn were not different between the groups, staiistically significant differences were observed for GSH, NO, and Cu levels when compared to control group. AOPP levels were statistically increased in group 1 compared to control group. It can be suggested that hyperglycernia in DNI is associated with accelerated nonenzymatic glycation and oxidative stress.