Effects of chronic L-DOPA administration on neurogenic and endothelium-dependent relaxation responses in rabbit corpus cavernosum


Yildirim S., ÖZTÜRK FİNCAN G. S. , Isli F., Ercan S., Sarioglu Y.

PHARMACOLOGICAL REPORTS, vol.68, no.5, pp.926-934, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1016/j.pharep.2016.04.012
  • Journal Name: PHARMACOLOGICAL REPORTS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.926-934

Abstract

Background: Dopamine is a crucial central neurotransmitter that plays a fundamental role in the autonomic and somatic components of penile reflexes in animals and humans. Similar to the erectile responses of dopamine, systemic administration of L-DOPA induces yawning and penile erection in some species. The possible effects of L-DOPA on nitric oxide (NO)-dependent and-independent non-adrenergic non-cholinergic (NANC) relaxation responses mediated by electrical field stimulation (EFS) and endothelium-dependent relaxation were investigated in this study.