Akademik Veri Yönetim Sistemi
INTERNATIONAL DAIRY JOURNAL, cilt.173, 2026 (SCI-Expanded, Scopus)
Background: This study investigated the effects of kefir consumption on lipopolysaccharides (LPS), LPS-binding protein (LBP), and miRNA-155 expression in obesity. Methods: Thirty-two obese women and 22 normal-weight controls were included. Obese participants on a calorie-restricted diet were assigned to a kefir group (250 ml twice daily for 4 weeks) or a non-kefir group. LPS, LBP, and miRNA-155 were measured. Results: Reductions in BMI, body circumferences, and body fat were similar in both obese groups. Fasting plasma glucose decreased significantly only in the kefir group. Baseline LPS levels were similar. After 4 weeks, LPS decreased in both obese groups compared with controls (p = 0.002), with a significant reduction observed only in the kefir group (p = 0.049). LBP remained unchanged (p > 0.05). miRNA-155 expression was elevated in obese participants at baseline (p = 0.01), similar between kefir and non-kefir subgroups (p > 0.05), and decreased significantly only in the kefir group at follow-up (p = 0.005). Conclusions: Kefir may serve as a complementary beverage in obesity management although it does not promote weight loss. Larger and longer-term studies are needed.