Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity


Doğruer D. S. , Urlu S., Önkol T., Özçelik B., Sahin M. F.

TURKISH JOURNAL OF CHEMISTRY, vol.34, no.1, pp.57-65, 2010 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.3906/kim-0904-27
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.57-65
  • Keywords: Pyridazine derivatives, antibacterial activity, antifungal activity, AGENTS, INHIBITORS, POTENT

Abstract

Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by H-1-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 mu g/mL) and E. coli (MIC ranging from 4 to 16 mu g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 mu g/mL.