Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Doğruer D. S. , Urlu S., Önkol T. , Özçelik B. , Sahin M. F.

TURKISH JOURNAL OF CHEMISTRY, cilt.34, sa.1, ss.57-65, 2010 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Konu: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3906/kim-0904-27
  • Sayfa Sayıları: ss.57-65


Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by H-1-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 mu g/mL) and E. coli (MIC ranging from 4 to 16 mu g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 mu g/mL.