Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

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Doğruer D. S., Urlu S., Önkol T., Özçelik B., Sahin M. F.

TURKISH JOURNAL OF CHEMISTRY, cilt.34, sa.1, ss.57-65, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3906/kim-0904-27
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.57-65
  • Anahtar Kelimeler: Pyridazine derivatives, antibacterial activity, antifungal activity, AGENTS, INHIBITORS, POTENT
  • Gazi Üniversitesi Adresli: Evet

Özet

Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by H-1-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 mu g/mL) and E. coli (MIC ranging from 4 to 16 mu g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 mu g/mL.