RETROSPECTIVE EVALUATION OF CASES OF COLCHICINE TOXICITY IN A PEDIATRIC INTENSIVE CARE UNIT


YAKUT H. İ. , Ayar G., Şahin S., UYSAL YAZICI M., Gündüz R. C. , KALKAN G.

NOBEL MEDICUS, vol.11, no.2, pp.24-48, 2015 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 2
  • Publication Date: 2015
  • Journal Name: NOBEL MEDICUS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.24-48
  • Keywords: Colchicine, poisoning, pediatric intensive care unit, ACUTE-RENAL-FAILURE, OVERDOSE, INTOXICATION, CHILDREN, DEATHS
  • Gazi University Affiliated: Yes

Abstract

Objective: Colchicine is a pharmacological agent used in the treatment of many rheumatic diseases such as gout, psoriasis and Familial Mediterranean Fever. Colchicine toxicity is uncommon and it is associated with high morbidity and mortality. Colchicine is known to have a narrow therapeutic index and the exact toxic dose seems to be unknown. In this article, we review factors that should be considered when prescribing colchicine, its presentation form in pharmacy and storage conditions.