RETROSPECTIVE EVALUATION OF CASES OF COLCHICINE TOXICITY IN A PEDIATRIC INTENSIVE CARE UNIT

YAKUT H. İ., Ayar G., Şahin S., UYSAL YAZICI M., Gündüz R. C., KALKAN G.

NOBEL MEDICUS, cilt.11, sa.2, ss.24-48, 2015 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2015
  • Dergi Adı: NOBEL MEDICUS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.24-48
  • Anahtar Kelimeler: Colchicine, poisoning, pediatric intensive care unit, ACUTE-RENAL-FAILURE, OVERDOSE, INTOXICATION, CHILDREN, DEATHS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Colchicine is a pharmacological agent used in the treatment of many rheumatic diseases such as gout, psoriasis and Familial Mediterranean Fever. Colchicine toxicity is uncommon and it is associated with high morbidity and mortality. Colchicine is known to have a narrow therapeutic index and the exact toxic dose seems to be unknown. In this article, we review factors that should be considered when prescribing colchicine, its presentation form in pharmacy and storage conditions.