TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.35, sa.2, ss.131-137, 2010 (SCI-Expanded)
Objective: Symptoms such as anorexia and sleep disturbances are common and cause a significant reduction in quality of life in hemodialysis patients. Orexin-A, which is a neuropeptide produced in lateral hypothalamic neurons and involved in regulation of feeding behavior, energy metabolism and sleep-wake cycle, is a good candidate to play a role in sleep and feeding disturbances in these patients. The aim of this study was to investigate the relationship between orexin-A levels and anorexia and sleep disturbances in hemodialysis patients.