Pectin-hydroxypropylmethylcellulose drug delivery system for colon targeting - Design and in vitro evaluation

Turkoglu M., Takka S., Baran H., Sakr A.

PHARMAZEUTISCHE INDUSTRIE, cilt.61, sa.7, ss.662-665, 1999 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 7
  • Basım Tarihi: 1999
  • Dergi Adı: PHARMAZEUTISCHE INDUSTRIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.662-665
  • Gazi Üniversitesi Adresli: Evet

Özet

Pectin-Hydroxypropylmethylcellulose (HPMC) matrix tablets were prepared and evaluated of their dissolution/erosion properties to assess their colon targeting:possibility based on a gastrointestinal transit time concept. Dosage forms were tested in water and also separately in 0.1 N HCl and pH 6.8 buffer systems. HPMCs of three different molecular weights were incorporated as 25% into a pectin USP matrix in addition to pure pectin tablets. The effect of a pectin-degrading enzyme (Pectinex 3XL) on dissolution rate was also studied. It was found that dissolution/erosion rates were faster in water than in buffer solutions. The t(50) Values were 3, 3.4, 5.0, and 6.0 h in water and 4.6, 5.3, 9.7, and 11.7 h in a buffer system dependent on the viscosity grade of HPMC. Addition of 25% HPMC improved the mechanical properties of pectin matrix. Pectinex 3XL accelerated the degradation of pectin tablets as well as HPMC content of matrix. Pectin-HPMC system is recommended as protective wall layers to protect and carry protein drugs to the colon for targeting.