Akademik Veri Yönetim Sistemi
CHEMISTRYSELECT, cilt.9, sa.34, 2024 (SCI-Expanded)
In our quest to develop new treatments for cancer, we synthesized and tested a series of urea-functionalized aminothiazole-benzazole analogs. Our primary focus was assessing their ability to inhibit the growth of breast cancer (MCF-7) and lung adenocarcinoma (A549) cells. Using H-1 NMR, C-13 NMR spectra, and high resolution mass spectrometry (HRMS), we confirmed the chemical structures of these compounds. Among them, compound 8a demonstrated significant cytotoxicity against MCF-7 cells, achieving an IC50 value of 9.6 +/- 0.6 mu M. Similarly, compound 8e exhibited potent cytotoxicity against A549 cells, with an IC50 value of 9.2 +/- 1.1 mu M. We further investigated the antimigration properties of all compounds that showed promising antiproliferative effects in both MCF-7 and A549 cells. Additionally, we evaluated how these compounds impact key apoptosis-related proteins: Caspase-7, PARP-1, BAX, and Bcl-2. These proteins play crucial roles in the regulation of programmed cell death. Overall, our findings suggest that these urea-functionalized aminothiazole-benzazole analogs hold promise as potential anticancer agents, warranting further exploration into their mechanisms of action and therapeutic potential.