Synthesis, characterization, and antibacterial activity of the ligands including thiophene/furan ring systems and their Cu(II), Zn(II) complexes

BALABAN GÜNDÜZALP A., ÖZBEK N., KARACAN N.

MEDICINAL CHEMISTRY RESEARCH, cilt.21, sa.11, ss.3435-3444, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 11
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00044-011-9878-8
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3435-3444
  • Anahtar Kelimeler: Carboxamides, 2-Thiophenecarbonyl chloride, 2-Furancarbonyl chloride, 4-Bis(3-aminopropyl)piperazine, Antibacterial activity, Microdilution method, METAL-AMIDE BOND, SCHIFF-BASE LIGANDS, ANTIMICROBIAL ACTIVITY, BIOLOGICAL-ACTIVITIES, SEMICARBAZONE, DONOR
  • Gazi Üniversitesi Adresli: Evet

Özet

Carboxamide complexes having general formula as [ML]Cl-2 center dot nH(2)O (where M = Cu(II), Zn(II); n = 0, 1/2) were synthesized using heterocyclic carboxamide ligands: 1,4-bis[3-(2-thiophenecarboxamido)propyl]piperazine (L-1) and 1,4-bis[3-(2-furancarboxamido) propyl]piperazine (L-2). Their structures were characterized with elemental analysis, molar conductivity, magnetic susceptibility, and spectral methods (H-1-NMR, C-13-NMR, FT-IR, LC-MS). TGA and DTA curves were also performed. The structure-activity relationship for the ligands was investigated using PM3 semi-empirical method. The antibacterial activities of the carboxamides and their complexes were investigated against bacteria; Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 11230, Bacillus magaterium RSKK 5117, B. cereus RSKK 863, Salmonella enteritidis ATCC 13076, B. subtilis RSKK 244 using microdilution method.