Determination of antiviral activity and cytotoxicity of selected sage (Salvia L.) species


ÖZÇELİK B. , ERDOĞAN ORHAN İ. , Kan Y.

Fabad Journal of Pharmaceutical Sciences, vol.36, no.3, pp.155-160, 2011 (Refereed Journals of Other Institutions) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2011
  • Title of Journal : Fabad Journal of Pharmaceutical Sciences
  • Page Numbers: pp.155-160

Abstract

The objective of this study was to examine antiviral property and cytotoxicity of the extracts prepared from the selected Salvia species (Lamiaceae) growing in Turkey. The chloroform and methanol extracts from 14 Salvia species (S. albimaculata, S. aucheri var. canescens, S. candidissima subsp. occidentalis, S. ceratophylla, S. cryptantha, S. cyanescens, S. frigida, S. forskahlei, S. halophila, S. migrostegia, S. multicaulis, S. sclarea, S. syriaca, and S. verticillata subsp. amasiaca) were tested against Herpes simplex (type-1, HSV-1) and Parainfluenza (type-3, PI-3) using Madin-Darby Bovine Kidney and Vero cell lines. Cytotoxicity of the extracts was determined as maximum non-toxic concentrations (MNTCs). The chloroform extracts of S. cyanescens and S. microstegia were found to inhibit both HSV-1 and PI-3 effectively. Therefore, these species could proceed to further evaluation for their possible antiviral components.