Akademik Veri Yönetim Sistemi
Ulusal Romatoloji Dergisi, cilt.15, sa.2, ss.73-81, 2023 (Scopus)
Objective: In the present study, we wanted the investigate the
reliability and validity of S100 biomarkers in the differential diagnosis
of IgG4-related disease (IgG4-RD) and to examine the relationship
between two-dimensional shear wave elastography (2D-SWE) scores
of parotid/lacrimal glands, which is used as an effective auxiliary tool
in disease prognosis.
Methods: Twenty-seven amyloidosis, 17 sarcoidosis, 13 IgG4-RD,
and 21 healthy controls (HCs) presenting to rheumatology outpatient
clinic were included in this cross-sectional study. S100A8, S100A9,
S100A12, and S100A8/A9 (calprotectin) protein levels were detected
with the ELISA test. Evaluation of all groups of the parotid and lacrimal
glands were performed using 2D-SWE.
Results: There was no significant difference between patient and
healthy control groups with respect to age, sex, and body mass index.
The mean levels of S100A9 and S100A12 proteins were significantly
higher in amyloidosis (S100A9; 25.09±7.92 vs. 12.91±8.74, S100A12;
627.87±643.83 vs. 344.03±118.02, p=0.001) and sarcoidosis groups
(S100A9; 23.67±12.34 vs. 12.91±8.74, S100A12; 600.4±381.26 vs.
344.03±118.02 p=0.001) compared to HCs. The calprotectin levels
were significantly higher in amyloidosis than IgG-RD and HCs. For
the parotid and lacrimal glands, the mean shear wave elasticity mode
values were significantly higher in the IgG4-RD patient compared with
HCs, amyloidosis, and sarcoidosis groups (all p=0.001), respectively.
2D SWE scores in parotid glands, reflecting loss of elasticity, had a
positive correlation with S100A9 level in IgG4-RD (r=0.948, p=0.014).
Conclusion: Results of this study suggest that S100A9, S100A12, and
calprotectin are promising biomarkers and might facilitate differential
diagnosis of IgG4-RD, sarcoidosis, and amyloidosis. S100A9 and
parotid elasticity could be novel biomarker and tool for the assessment
of activity status in patients with IgG4-RD.